INSULIN-LOADED POLYMERIC MUCOADHESIVE NANOPARTICLES: DEVELOPMENT, CHARACTERIZATION AND CYTOTOXICITY EVALUATION

Insulin-loaded polymeric mucoadhesive nanoparticles: development, characterization and cytotoxicity evaluation

Abstract Mucoadhesive nanoparticles are particularly interesting for delivery through nasal or pulmonary routes, as an approach to overcome the mucociliary clearance.Moreover, these nanoparticles are attractive for peptide and protein delivery, particularly for insulin to treat diabetes, as an alternative to conventional parenteral administration.T

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A Fully Cognitive Approach for Future Internet

This paper deals with an autonomous cognitive network management architecture which aims at achieving inter-network (horizontal) ANTI-AGING BEAUTY and inter-layer (vertical) cross-optimization.The proposed architecture is based on the so-called Cognitive Managers transparently embedded in properly selected network nodes.The core of each Cognitive M

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The hypoxia-driven crosstalk between tumor and tumor-associated macrophages: mechanisms and clinical treatment strategies

Abstract Given that hypoxia is a persistent physiological feature of many different solid tumors and a key driver for cancer malignancy, it is thought to be a major target in cancer treatment recently.Tumor-associated macrophages (TAMs) are the most abundant immune cells in the tumor microenvironment Backpacks (TME), which have a large impact on tu

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